Head and neck cancers generally refer to cancers that start in the head and neck area, excluding brain cancer and thyroid cancer but including the lips, tongue, oral cavity, salivary glands (parotid glands), tonsils, throat/ larynx, nasopharynx, nasal cavity, and the paranasal sinuses.
There are more than 1,600 new cases of head and neck cancers in Hong Kong each year. More than half of them are nasopharyngeal carcinomas (NPC), and nearly half of the newly diagnosed patients are between 40 and 59 years old. The male to female incidence ratio is 2.7:1.
Genetics: family history of head and neck cancer
Human papillomavirus (HPV) infection
Drinking excessive amounts of alcohol
EB (Epstein-Barr) virus infection: risk of nasopharyngeal cancer increases by 30 times
Paranasal sinuses or nasopharynx: epistaxis (nosebleeds), unilateral hearing loss
Oral cavity or tongue: persistent ulcers, leukoplakia, bleeding of the gums
Tonsils: unilateral sore throat or earache, oral bleeding
Throat: hoarseness, coughing up blood (hemoptysis), difficulty in breathing
Hypopharynx: neck swelling, difficulty in swallowing, blood-stained saliva
Screening and Diagnosis
Head and Neck Cancer Screening and Diagnosis:
EBV antibody blood test or DNA concentration blood test for nasopharyngeal cancer index
Biopsy tests where tissue is extracted from the suspected location
More than half of head and neck cancer patients do not experience symptoms until the cancer is at an advanced stage. However, early screening allows doctors to diagnose cancer early and increases the chance of successful treatment for early-stage head and neck cancer.
Tumor Metastasis and Stage:
Computed tomography (CT) scan
Magnetic resonance imaging (MRI)
Positron emission tomography and computed tomography scan (PET-CT Scan)
Surgery removes the tumor(s) more directly and completely. It can also be performed in combination with other treatments, though not all head and neck cancers are suitable for surgery.
Radiation Therapy (Radiotherapy)
Radiation therapy is the use of high-energy radiation to destroy cancer cells. New systems such as Tomotherapy, a high-speed helical radiation system, direct radiation energy at the tumor(s), minimizing exposure of energy to normal cells and reducing the development of possible side effects. This helps reduce negative effects on the salivary glands, vision, hearing, and spinal nerves.
Chemotherapy is treatment with drugs to destroy cancer cells in an effort to shrink the tumors or control their growth. Depending on the patient’s condition, concurrent radiochemotherapy, induction chemotherapy, and palliative chemotherapy may be performed.
Concurrent radiochemotherapy is the regular administration of chemotherapy during the course of radiation therapy to enhance the effect of radiation therapy. It is generally used for the treatment of nasopharyngeal carcinoma/cancer, tonsil cancer, and throat cancer. Induction chemotherapy involves multiple administrations of chemotherapy before surgery or radiation therapy. It aims to shrink the tumor(s), reduce the risk of recurrence, and reduce the extent of radiation therapy.
Targeted therapy employs molecular biology techniques that focus on the mechanisms by which cancer cells mutate, proliferate, and spread in an effort to inhibit their ability to grow and repair. Depending on the circumstances, it may be used on its own, or as a method to reinforce the effect of chemotherapy.